There are a lot of conferences. And more and more are in the fields of social entrepreneurship, clean technology and green business. Just this weekend, one could attend Poptech in Maine, Social Venture Network in La Jolla or the Energy Justice Program in Boulder. Is this a good thing? What is all this conferring doing to make the world a better place? Here are a few issues that concern me.
Saturday, October 24, 2009
Conflicted on Conferences
Sunday, October 11, 2009
A BIG Deal
In 2003, two guys (with whom I used to work) started a company. No big deal. Happens all the time.
At first, the company looked at using some new vaccine delivery technology. Both guys had other jobs. But they wanted to build a company together. They had a start on the WHO, but not really the WHAT yet.
But they were fortunate. One of them lived in a town where the Centers for Disease Control has laboratories. And where the land grant university has a number of scientists working on infectious diseases in the developing world. And a few non-profits that were working on products and services to improve public health in the developing world. And it probably didn't hurt that there were a few good local breweries to support "beer storming" ideas. An idea for a company began to evolve.
And these guys were knowledgeable. They knew about doing research. They knew about drug development. They had worked at top research universities and in the biotech and pharmaceutical industries. They had a lot of respect for what the drug companies did. But they also wondered about what the drug companies didn't do. One thing the drug companies didn't do was develop many drugs or vaccines for the billions of people in the developing world. Their business models didn't work for these markets. Their pipelines were focused on the diseases of the affluent- expensive medicines and treatments for chronic diseases. The developing world was a place for off-patent medicines or the occasional charitable venture, not a place to target R&D efforts.
So these guys thought about how they could build a company that created products for those billions of people. They studied the markets. They spoke with early leaders like One World Health. Could they do research on new vaccines? Instead of expensive treatments, could they develop affordable vaccines that would prevent disease. Could they develop products that would also work for the middle class in these countries? For travelers to these countries?
Well, from those ideas, they started building a company. Global from the start. To develop vaccines to fight infectious diseases. Top quality research, top quality manufacturing. Partnerships with clinics around the world. Picking diseases, such as dengue fever, which did not receive much attention from other companies, but had huge impacts on public health. A big idea, maybe. But still not a big deal.
At first, they got told they were well intentioned, but crazy. Why develop products for these less developed markets? Why develop vaccines, which don't have a continued revenue stream? Why move manufacturing outside Western countries? But they kept plugging away. And they began to win a few awards (Colorado's most promising biotech Business Plan in 2005). They raised some start up capital from friends (including me). They were awarded some grant funding from the NIH. With each step, they looked a bit less crazy. They added a few more smart, well-intentioned people to the team. A good idea, good people. But still not a big deal.
They knew that bringing a vaccine to market takes tens of millions of dollars. That was going to require venture capital, and venture capital requires competitive returns. In 2006, the company decided it was time to start raising money to start building the company. They pitched and pitched, making the case that these markets and diseases were attractive and that the company could profit from preventing these diseases. To put it diplomatically, they got a polite reception, but not an enthusiastic one. Professional investors asked some of the same tough questions about the markets and vaccine based business models.
Over time, the company stayed afloat, and the perceptions of this company, the attractiveness of its target markets and its business model, began to change. At several points, the situation looked dicey. But these guys, and their employees and partners, persevered. In 2008, they found a lead investor. Got a term sheet. But then the global financial crisis made it tough to fill out the group of investors. They survived and kept working. Which was a good thing, but not a big deal.
Finally, last week, more than three years after they started working on Series A and after over a hundred investor presentations, these guys, and their company Inviragen, closed the round. $15 million dollars. Enough to take the company through the early clinical trials of several vaccines. You can read more about the company at their website. And more about the Series A investment, and merger with Singapore based Singvax, in their press release.
So, why do I think this is a big deal? It's not because of the money (although that is certainly helpful). It is because of whose money it is. Sometimes you hear an entrepreneur say "all money's green; who cares who the investor is." Well, those entrepreneurs are wrong. It matters who your investors are. And Inviragen's investors are top notch biotech VC's. Experienced. Main stream. Connected to a network of people who know how to bring products to market. They found Inviragen to be a compelling investment.
This is one of the first of what I hope to be many deals where mainstream investors see the benefits of starting high tech ventures that serve global markets, including the poor. And I hope that it shows that the drive for attacking global public health challenges can be very profitable for investors. That the value they create can attract top private capital firms. In fact, I hope it shows that the financial returns required of this venture will drive the successful commercialization of several vaccines, saving thousands and thousands of lives. And yes, I think that is a BIG deal.
Congratulations to Dan Stinchcomb, Jorge Osario and the rest of the Inviragen team, and best of luck in continuing your worthy work.
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Note: I am not an unbiased source. I have known Dan and Jorge for years, and was an early investor in their company. I also served as a director of the company until recently.
Tuesday, September 22, 2009
3 Billion Served?
When I was a kid, the McDonald's signs kept me updated on how many billions had been served. The year I was born (1958), in it's 10th year of business, it hit 100 million. When I turned 5, McDonalds hit 1 billion. About the time I reached 6 feet, it reached 10 billion burgers. By 1984, when I graduated from law school, McD's reached 50 billion. A few years later it stopped counting.
What does this have to do with BOPreneurs? Well, this simple metric illustrates a great example of scaling up an international business. Jim Collin's writes about the flywheel effect of gradual, increasing momentum in a business. For McDonalds, part of this came from potent branding and marketing to a newly mobile population. But the other part came from a solid franchise model. This let them experience logarithmic growth without exploding, and allowed them to leverage other people's human and financial capital.
Yesterday, Jason Fairbourne of BYU's Economic Self Reliance Center, visited CSU to talk about his work in applying franchise principles to BOP markets. Fairbourne persuasively made the case that this is a promising approach for both large companies and growing ventures. Borrowing from his research on companies such as VisionSpring and Fan Milk, as well as his own work with a new start up in Ghana, Fairbourne proposes a straightforward framework for "micro-franchising."
1. Find a Successful BOP Business. He didn't say this was easy, and it takes getting out into the field. You won't find these at conferences or in a library. On the other hand, since many of the businesses in BOP are hawkers, you might be successful by looking at "businesses that aren't hawkers." Or not exactly hawkers. It takes a little observation to see that Fan Milk is not just hawkers selling yogurt or ice cream in Ghana, but a sophisticated, profitable organization with low turnover of its bicycle based franchisees. If you are a BOPreneur, microfranchising is not your strategy, but it is a tactic you can use once you have proven your business model.
2. Systematize it. What is the venture's business model? What are leverage points that come with growth? Look at issues of branding, supply chain logistics, territory, contracts and operations manual. The idea is to remove the "creative burden" required for a new entrepreneurial venture, and move to a system which a manger can operate. By doing this, the franchisor reduces risks and enhances income generation for the franchisee. Note that Fairbourne isn't advocating for the demise of entrepreneurship in the BOP. But he is suggesting that those BOPreneurs wishing to "scale up" would be better off to rely on training microenterprise managers, rather than hoping to find an army of micro-entrepreneurs (which he has found to be in short supply).
3. Replicate it. Once the supply chain has been figured out, the manuals written, the managers trained and the business proven regionally, it is easier to replicate the concept into other territories and markets. This is where McDonalds excelled. Not all McDonalds were the same, but they were very similiar around the world. Local modifications may be neccessary as a venture enters new markets, but they should be kept to a minimum to enhance rapid growth. CSU students quizzed Fairbourne on how to decide where to start, and he suggested they pick regions with more stable governments and growing economies.
Fairbourne emphasised two big advantages he sees for this approach. First, it reduces the risk of failure for the business operator. Done properly, incentives for success and penalties for failure are better shared under Fairbourne's approach. Secondly, it connects informal operators to formal supply chains. In doing so, it has macroeconomic effects as these businesses become formalized and grow (not surprisingly, Fairbourne has discussed his approach with Hernando DeSoto's ILD as a way to promote development).
If you are interested in finding out more about micro-franchising, take a look at Fairbourne's book, the Microfranchise Toolkit, and David Stoker's blog. And certainly attend the conference he is hosting in early November (as a special BOP bonus, I'll be there too).
I was impressed with Fairbourne's talk, and the potential microfranchising offers for certain types of consumer focused businesses in the BOP. There is a lot of cheap talk on scaling up BOP ventures, but precious few examples of BOPreneurs that can claim "millions served" (IDE, Aravind, Grameen). The world could use a few "billions served" social enterprises, and if history is a guide, franchising might be a good way to get there.
